7/14/2023 0 Comments Vitamin k antidoteCytochrome c oxidase inhibition depletes intracellular adenosine triphosphate and increases oxidative stress, while increased nitric oxide causes hypotension and exacerbates oxidative damage. Azide inhibits mitochondrial cytochrome c oxidase and is likely oxidized to nitric oxide in vivo. No specific azide antidote exists, with treatment being solely supportive. Azide-poisoned patients present with vomiting, seizures, hypotension, metabolic acidosis, and coma death can occur. ![]() ![]() ![]() It exists most commonly as sodium azide, which is used widely and is readily available, raising the potential for occupational incidents and use as a weapon of mass destruction.
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